Lianrui Zuo
Atlas
2001

Linear registration

We can score how well two scans match for any rotation, shift or stretch. With far too many candidates to try them all, how do we find the best one?

Primary source M. Jenkinson and S. Smith, “A global optimisation method for robust affine registration of brain images,” Medical Image Analysis, vol. 5, no. 2, pp. 143–156, 2001. doi:10.1016/S1361-8415(01)00036-6

The moving image is a head slice turned by 150°. A computer turns it back a little at a time, always in the direction in which the match gets better, until no small turn helps. The curve shows how poor the match is at every angle. Pick a start and press Run: from some starts it ends at 150° with the head upright, from others it stops with the head upside down, at the bottom of a different valley.

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